BCN-PEG4-Glu-Gly-Cit-PAB-MMAE is a precursor of antibody drug conjugates (ADCs) containing a cleavable Glu-Gly-Cit (EGCit) peptide and a click-reactive BCN which can conjugate with an azide-containing moiety or monoclonal antibody (mAb). This peptide demonstrates exceptional durability in the bloodstream, remaining resistant to degradation and neutrophil protease cleavage, all while discreetly and tracelessly releasing payloads inside cells.
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