TCO-PEG4-Val-Cit is a cleavable ADC linker featuring a TCO group, a hydrophilic PEG spacer, and a Val-Cit dipeptide. TCO is a click chemistry handle which readily reacts with tetrazine groups on a target molecule while Val-Cit dipeptides are cleaved by cytoplasmic peptidases to enable rapid and efficient drug delivery.
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