PROTAC Linkers

PROTAC Linkers

PROTAC linker is a crosslinker that connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.  Most commonly used protac linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether. Insertion of PEG increases the water-solubility of the molecules.
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