DBCO-PEG4-NHS ester

DBCO-PEG4-NHS ester


DBCO-PEG4-NHS Ester is a click chemistry PEG reagent containing NHS ester that is able to react specifically and efficiently with primary amines (e.g. the side chain of lysine residues or aminosilane-coated surfaces) at neutral or slightly basic condition to form a covalent bond. The hydrophilic PEG spacer arm improves water solubility and provides a long and flexible connection that minimizes steric hindrance involved with ligation. DBCO is commonly used for copper-free Click Chemistry reactions. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Molecular structure of the compound BP-22288
    • Unit
    • Price
    • Qty
    • 25 MG
    • $235.00
    • 100 MG
    • $595.00
    • 250 MG
    • $1150.00
    • 500 MG
    • $1850.00

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Product Citations


  1. Krishnan, M. A., Alimi, O. A., Pan, T., Kuss, M., Korade, Z., Hu, G., ... & Duan, B. (2024). Engineering Neurotoxin-Functionalized Exosomes for Targeted Delivery to the Peripheral Nervous System. Pharmaceutics, 16(1), 102.
    https://www.mdpi.com/1999-4923/16/1/102
  2. Mauser, Ava, Daniel F. Quevedo, Boya Zhang, Yazmin Hernandez, Anthony Berardi, William Brown, Sophia Lee Enzyme-based Synthetic Protein Nanoparticles as Colloidal Antioxidants. Advanced Therapeutics. 2023
    https://onlinelibrary.wiley.com/doi/full/10.1002/adtp.202300007
  3. Studer, Tetiana, Daria Morina, Inga S. Shchelik, and Karl Gademann.  Biohybrid Microswimmers for Antibiotic Drug Delivery Based on a Thiol-Sensitive Release Platform. Chemistry-A European Journal. 2023
    https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/chem.202203913